4th Edition
Textbook of Diabetes and Pregnancy
Written by a cadre of experts, this new edition provides a comprehensive, authoritative, and international view of gestational diabetes mellitus and will be invaluable to maternal-fetal medicine specialists, diabetologists, neonatologists, and a growing number of gynecologists and general physicians concerned with the management of noncommunicable diseases in pregnancy.
- Offers a comprehensive and authoritative guide to all aspects of the subject internationally
- Presents an invaluable resource for all working in diabetes, maternal-fetal medicine, and obstetrics
- Shows the latest developments in research in genomics and in practice with the digital clinic
In Memoriam: Oded Langer† by Yariv Yogev
Honoring Lois Jovanovič (1947–2018) by Alejandra de Leiva-Pérez and Alberto de Leiva-Hidalgo
Preface
List of Contributors
1 Prologue: Maternal Medicine Meets Fetal Medicine: Merging the Legacies and Hypotheses
Moshe Hod, Kypros Nicolaides, Hamutal Meiri, and Nicky Lieberman
2 History of Diabetic Pregnancy
David R. Hadden†, Alejandra de Leiva-Perez, and Alberto de Leiva-Hidalgo
3 Epidemiology of Gestational Diabetes Mellitus
Yariv Yogev, Avi Ben Haroush, Moshe Hod, and Jeremy Oats
4 The Great Obstetric Syndromes: The Roots of Disease
Rinat Gabbay-Benziv and Ahmet A. Baschat
5 Metabolism in Normal and in Diabetic Pregnancy
Emilio Herrera and Henar Ortega-Senovilla
6 Nutrient Delivery and Metabolism in the Fetus
William W. Hay
7 Pathogenesis of Gestational Diabetes Mellitus
Yariv Yogev
8 Autoimmunity in Gestational Diabetes Mellitus
Alok Kumar, Lilian C. Mendoza, Didac Mauricio, Rosa Corcoy, and Alberto de Leiva-Hidalgo
9 The Placenta in Diabetic Pregnancy
Laura Avagliano, Margaret Mascherpa, and Gaetano Bulfamante
10 Gestational Diabetes Mellitus: The Consequences of Not Treating
Oded Langer†
11 Implications of Diabetic Pregnancy: The Offspring
Kit Ying Tsoi, Wing Hung Tam, and Ronald Ching Wan Ma
12 Short-Term Implications: The Neonate
Paul Merlob, Sharon Hod, and Moshe Hod
13 Implications of Diabetic Pregnancy: The Mother
Garry X. Shen and Kaberi Dasgupta
14 Gestational Diabetes Mellitus, Obesity and Pregnancy Outcomes
Gillian A. Corbett and Fionnuala M. McAuliffe
15 Hypertensive Disorders and Diabetic Pregnancy
Lo Wong, Melanie Nana, and Liona C. Poon
16 Fetal Congenital Malformations in Diabetic Pregnancy
Conrado Savio Ragazini, Cristiane de Freitas Paganoti, Conrado Milani Coutinho, and Fabricio da Silva Costa
17 Post-Implantation Diabetic Embryopathy
Ulf J. Eriksson and Parri Wentzel
18 Congenital Malformations in Diabetic Pregnancy: Prevalence and Types
Paul Merlob
19 Reproduction and Its Impact on Health and Disease
Sara Ornaghi and Michael J. Paidas
20 Prediction and Prevention of Gestational Diabetes Mellitus
Harold David McIntyre
21 Inositols and Prevention of Gestational Diabetes Mellitus
Fabio Facchinetti, Serena Lecis, and Pierluigi Di Vinci
22 The Multiomics Approach to Diabetes in Pregnancy
Abraham Tsur
23 The Role of Bariatric Surgery in Obese Women Planning Pregnancy
Ron Charach, Tifferet Willner, and Eyal Sheiner
24 The Role of Glucagon-Like Peptide-1 (GLP-1) in Women with Obesity Planning Pregnancy
Yoel Toledano and Moshe Hod
25 Diagnosis of Gestational Diabetes Mellitus
Federico Mecacci, Serena Ottanelli, and Giorgio Mello
26 Glucose Intolerance in Pregnancy: A Window to Mother and Offspring Future Cardio-Metabolic Risk
Maya Karen Nitecki and Gilad Twig
27 Ideal Weight Gain in Pregnancy with Diabetes
Gillian A. Corbett and Fionnuala M. McAuliffe
28 Glycemic Goals in Diabetic Pregnancy and Defining "Good Control": Maternal and Fetal Perspective
Tomer Avnon, Yariv Yogev, and Liran Hiersch
29 Medical Nutritional Therapy for Gestational Diabetes Mellitus
Alejandra de Leiva-Perez, Lois G. Jovanovič†, and Alberto de Leiva-Hidalgo
30 Insulin Therapy in Pregnancy
Lene Ringholm, Sidse Kjarhus Norgaard, and Elisabeth R. Mathiesen
31 Use of Non-Insulin Antihyperglycemic Drugs in Relation to Pregnancy
Montserrat Balsells, Apolonia Garcia-Patterson, and Rosa Corcoy
32 Continuous Subcutaneous Insulin Infusion and Continuous Glucose Monitoring in Pregnancy
Eytan Roitman
33 Periconceptional Assessment in Diabetic Women Planning Pregnancy
Elisabetta Torlone and Annunziata Lapolla
34 Early Pregnancy Loss and Perinatal Mortality
Mariane Silve Edge and Hassan Shehata
35 Fetal Surveillance in Diabetic Pregnancies
Monica Centeno and Diogo Ayres-de-Campos
36 Timing and Mode of Delivery in Diabetic Pregnancy
Rodney McLaren Jr. and Vincenzo Berghella
37 Management of the Macrosomic Fetus: Can Fetal Macrosomia Be Predicted and Prevented?
Federico Mecacci, Marianna Pina Rambaldi, and Giorgio Mello
38 Gestational Diabetes in Twin Pregnancies
Nir Melamed and Liran Hiersch
39 Fetal Growth Restriction in Diabetic Pregnancies
Sharon Alpern, Isca Landesberg, Nir Melamed, and Liran Hiersch
40 Diabetes, Obesity, Hypertension, and Preterm Birth
Ann Rowan and Michael Geary
41 Diabetic Retinopathy
Jennifer Fu, Ilana Halperin, and Nir Melamed
42 Diabetic Kidney Disease
Lene Ringholm, Nicoline Callesen-Do, Marianne Jenlev Vestgaard, Peter Damm, and Elisabeth R. Mathiesen
43 Diabetic Ketoacidosis
Annunziata Lapolla, Giovanni Sartore, and Maria Grazia Dalfrà
44 Thyroid In Pregnancy
Yoel Toledano
45 Gestational Diabetes in Lower- and Middle-Income Countries
Hema Divakar, Anne Beatrice Khiara, and Moshe Hod
46 Managing Diabetic Pregnancy in China
Chen Wang, Rina Su, and Huixia Yang
47 Links between Maternal Health and Noncommunicable Diseases
Anil Kapur
48 Diabetes, Pregnancy, and the Developmental Origins of Health and Disease
Gerard H.A. Visser and Mark A. Hanson
49 Postpartum Management: Mother and Offspring
Shayna Miodownik, Omri Zamstein, and Eyal Sheiner
50 Non-Invasive Glucose Monitoring
Eran Hadar and Moshe Hod
51 Closed-Loop Insulin Delivery in Type 1 Diabetes Pregnancy
Zoe A. Stewart and Helen R. Murphy
52 Epilogue: Maternal Fetal Medicine Meets Femtech while Digitalizing Pregnancy Management: Present and Future
Moshe Hod, Hema Divakar, Anne Beatrice Kihara, and Michael Geary
Index
Biography
Moshe Hod is the Director, Mor Comprehensive Women’s Health Care Center, Tel-Aviv, Israel
Nir Melamed is the Head of Twins Research Centre, Director of Research, Maternal-Fetal Medicine Division, Sunnybrook Health Sciences Centre, University of Toronto, Canada
Gian Carlo Di Renzo is a Professor of Obstetrics and Gynecology and Maternal Fetal Medicine, Coordinator of the Reproductive and Perinatal Medicine Center, University of Perugia; Founder and Director, PREIS International School, Firenze, Italy; and Director, Alliance of Global Women’s Medicine, GLOWM, London, UK
Hema Divakar is a Gynecologist and Obstetrician at Divakar Specialty Hospital, Bangalore, India
Alberto de Leiva is the Scientific Director, Fundación DIABEM, Barcelona, Spain
Liona Poon is the department Chairperson AND Professor (Clinical), Co-Team Head for Maternal Medicine, Department of Obstetrics and Gynaecology, the Chinese University of Hong Kong and Prince of Wales Hospital, China
Huixia Yang is the department Director and Professor for Obstetrics and Gynecology and Reproductive Medicine, and Director for Beijing Key Laboratory of Maternal Fetal Medicine of Gestational Diabetes Mellitus, Peking University First Hospital, Beijing, China
Yariv Yogev is the Professor and Chairman, Lis Hospital for Women’s Health, Tel Aviv Sourasky Medical Center, and Head of Division of Obstetrics and Gynecology, Faculty of Medicine, Tel Aviv University, Israel
REVIEWS OF PREVIOUS EDITIONS
A comprehensive and detailed review of all aspects of management … an excellent reference book and a highly authoritative tome on an increasingly common condition. (Glycosmedia)An excellent job … presenting evidence-based guidance. (Doody’s Book Reviews)
An excellent general resource ... well-suited for the trainee, particularly in obstetrics, who will care for the pregnant woman with diabetes and her offspring. (New England Journal of Medicine)
An excellent resource for all clinicians caring for pregnant women with diabetes. I commend this textbook to any craving a fresh look at an old problem. (Diabetologia)
